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Sunday, August 19, 2007

Notable people with mesothelioma

Polio vaccines and the SV40 virusMore recently, it has been reported that a virus (SV40) contaminating some polio vaccine preparations may well be associated with mesothelioma, as some DNA sequences of the virus are sometimes found in cancerous mesothelial cells. These vaccine preparations had been produced in 1954, some eight years before SV40 was first isolated, and had been prepared by growing polio virus in cell cultures from rhesus monkey kidney cells. As a result, millions of people have been injected with SV40-contaminated polio vaccines.
Recent findings by Dr. M. Carbone and colleagues of the Dept. of Pathology at the University of Chicago and by co-workers at the National Cancer Institute first indicated that the SV40 virus, which induces mesothelioma in hamsters, is also oncogenic for humans. Later on, they found SV40-like DNA sequences in human mesothelioma cases (Carbone et al., 1994). Similar evidence is now beginning to appear from France and the U.K.
Recent evidence of the significance of the SV40 virus and other potential sources of mesothelioma, suggests that factors other than asbestos exposure may have played a role in recently reported mesothelioma cases in Europe in which the victims are reported to have had only casual, low level contact with asbestos-containing products.

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